The Use of Regional Anesthesia to Reduce Blood Loss in Isolated Limb Perfusion (ILP)-A Novel Approach.

ABSTRACT:

Background

Isolated limb perfusion (ILP) for soft tissue sarcomas (STS) is usually performed with tumor necrosis factor alpha (TNF-α) and melphalan. ILP regularly leads to a total blood loss (BLt) of 1.5-2 L/patient. Blood inflow from the central blood circulation to the limb is influenced by unstable pressure gradients and pain reactions after the administration of melphalan. With perioperative regional anesthesia (RA), pain levels can be reduced, and the pressure gradient stabilized resulting in a reduced BLt. The aim of this study was to compare the BLt with and without RA in patients with ILP during circulation of drugs.

Methods

Patients were treated according to the following protocol: After the establishment of limb circulation, ILP was started with the administration

SUBMITTER: Niethard M 

PROVIDER: S-EPMC10607281 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature