Structural Characterization of the Metalized Radical Cations of Adenosine ([Ade+Li-H]^•+ and [Ade+Na-H]^•+) by Infrared Multiphoton Dissociation Spectroscopy and Theoretical Studies.

ABSTRACT: Nucleoside radicals are key intermediates in the process of DNA damage, and alkali metal ions are a common group of ions in living organisms. However, so far, there has been a significant lack of research on the structural effects of alkali metal ions on nucleoside free radicals. In this study, we report a new method for generating metalized nucleoside radical cations in the gas phase. The radical cations [Ade+M-H]^•+ (M = Li, Na) are generated by the 280 nm ultraviolet photodissociation (UVPD) of the precursor ions of lithiated and sodiated ions of 2-iodoadenine in a Fourier transform ion cyclotron resonance (FT ICR) cell. Further infrared multiphoton dissociation (IRMPD) spectra of both radical cations were recorded in the region of 2750-3750 cm^-1. By combining these

SUBMITTER: Kou M 

PROVIDER: S-EPMC10607295 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature