Mitigating Age-Related Ovarian Dysfunction with the Anti-Inflammatory Agent MIT-001.

ABSTRACT: Ovarian aging is a major obstacle in assisted reproductive medicine because it leads to ovarian dysfunction in women of advanced age. Currently, there are no effective treatments to cure age-related ovarian dysfunction. In this study, we investigated the effect of MIT-001 on the function of aged ovaries. Young and old mice were utilized in this study. MIT-001 was intraperitoneally administered, and the number of follicles and oocytes was analyzed. Each group was then retrieved for RNA and protein isolation. Total RNA was subjected to mRNA next-generation sequencing. Protein extracts from ovarian lysates were used to evaluate various cytokine levels in the ovaries. MIT-001 enhanced follicles and the number of oocytes were compared with non-treated old mice. MIT-001 downregulated immune resp

SUBMITTER: Kang MH 

PROVIDER: S-EPMC10607328 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature