Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion.
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ABSTRACT:
SUBMITTER: Franzi E
PROVIDER: S-EPMC10607366 | biostudies-literature | 2023 Oct
REPOSITORIES: biostudies-literature
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Non-Steroidal Estrogens Inhibit Influenza Virus by Interacting with Hemagglutinin and Preventing Viral Fusion.
Franzi Elisa E Mathez Gregory G Dinant Soraya S Deloizy Charlotte C Kaiser Laurent L Tapparel Caroline C Le Goffic Ronan R Cagno Valeria V
International journal of molecular sciences 20231019 20
Influenza virus is one of the main causes of respiratory infections worldwide. Despite the availability of seasonal vaccines and antivirals, influenza virus infections cause an important health and economic burden. Therefore, the need to identify alternative antiviral strategies persists. In this study, we identified non-steroidal estrogens as potent inhibitors of influenza virus due to their interaction with the hemagglutinin protein, preventing viral entry. This activity is maintained in vitro ...[more]
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