Multisequence MRI-based radiomics model for predicting <i>POLE</i> mutation status in patients with endometrial cancer.

ABSTRACT:

Objectives

Preoperative identification of POLE mutation status would help tailor the surgical procedure and adjuvant treatment strategy. This study aimed to explore the feasibility of developing a radiomics model to pre-operatively predict the pathogenic POLE mutation status in patients with EC.

Methods

The retrospective study involved 138 patients with histopathologically confirmed EC (35 POLE-mutant vs 103 non-POLE-mutant). After selecting relevant features with a series of steps, three radiomics signatures were built based on axial fat-saturation T2WI, DWI, and CE-T1WI images, respectively. Then, two radiomics models which integrated features from T2WI + DWI and T2WI + DWI+CE-T1WI were further developed using multivariate logistic regres

SUBMITTER: Lin Z 

PROVIDER: S-EPMC10607390 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature