Ellagic Acid from Hull Blackberries: Extraction, Purification, and Potential Anticancer Activity.

ABSTRACT: Ellagic acid (EA) is present at relatively high concentrations in many berries and has many beneficial health effects, including anticancer properties. To improve the development and utilization of blackberry fruit nutrients, we divided Hull blackberry fruits into five growth periods according to color and determined the EA content in the fruits in each period. The EA content in the green fruit stage was the highest at 5.67 mg/g FW. Single-factor tests and response surface methodology were used to optimize the extraction process, while macroporous resin adsorption and alkali dissolution, acid precipitation, and solvent recrystallization were used for purification. The highest purity of the final EA powder was 90%. The anticancer assessment results determined by MTT assay showed that EA inh

SUBMITTER: Wang J 

PROVIDER: S-EPMC10607623 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature