Development and Validation of LC-MS/MS Method for Determination of Cytisine in Human Serum and Saliva.

ABSTRACT: Cytisine (CYT) is a quinolizidine alkaloid used for nicotine addiction treatment. Recent clinical trial data regarding cytisine confirm its high effectiveness and safety as a smoking cessation treatment. CYT's popularity is growing due to its increased availability and licensing in more countries worldwide. This increased use by smokers has also resulted in an urgent need for continued drug research, including developing appropriate analytical methods for analyzing the drug in biological samples. In this study, a simple, fast, and reliable method combining hydrophilic interaction liquid chromatography and electrospray ionization quadrupole time of flight mass spectrometry (HILIC/ESI-QTOF-MS) for the determination of CYT in human serum and saliva was developed and validated. This was undert

SUBMITTER: Wroblewski K 

PROVIDER: S-EPMC10607646 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature