Protein Disulfide Isomerase FgEps1 Is a Secreted Virulence Factor in Fusarium graminearum.

ABSTRACT: Protein disulfide isomerase (PDI) is a member of the thioredoxin (Trx) superfamily with important functions in cellular stability, ion uptake, and cellular differentiation. While PDI has been extensively studied in humans and animals, its role in fungi remains relatively unknown. In this study, the biological functions of FgEps1, a disulfide bond isomerase in the fungal pathogen Fusarium graminearum, were investigated. It was found that FgEps1 mutation affected nutritional growth, asexual and sexual reproduction, and stress tolerance. Additionally, its deletion resulted in reduced pathogenicity and impaired DON toxin biosynthesis. The involvement of FgEps1 in host infection was also confirmed, as its expression was detected during the infection period. Further investig

SUBMITTER: Liu K 

PROVIDER: S-EPMC10607971 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature