Molecular and Functional Analyses of Characterized Sesquiterpene Synthases in Mushroom-Forming Fungi.

ABSTRACT: Sesquiterpenes are a type of abundant natural product with widespread applications in several industries. They are biosynthesized by sesquiterpene synthases (STSs). As valuable and abundant biological resources, mushroom-forming fungi are rich in new sesquiterpenes and STSs, which remain largely unexploited. In the present study, we collected information on 172 STSs from mushroom-forming fungi with experimentally characterized products from the literature and sorted them to develop a dataset. Furthermore, we analyzed and discussed the phylogenetic tree, catalytic products, and conserved motifs of STSs. Phylogenetic analysis revealed that the STSs were clustered into four clades. Furthermore, their cyclization reaction mechanism was divided into four corresponding categories. This database

SUBMITTER: Wang S 

PROVIDER: S-EPMC10608071 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature