Untargeted Metabolomics Reveals Alterations of Rhythmic Pulmonary Metabolism in IPF.

ABSTRACT: Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive condition characterized by the impairment of alveolar epithelial cells. Despite continued research efforts, the effective therapeutic medication is still absent due to an incomplete understanding of the underlying etiology. It has been shown that rhythmic alterations are of significant importance in the pathophysiology of IPF. However, a comprehensive understanding of how metabolite level changes with circadian rhythms in individuals with IPF is lacking. Here, we constructed an extensive metabolite database by utilizing an unbiased reference system culturing with ¹³C or ¹⁵N labeled nutrients. Using LC-MS analysis via ESI and APCI ion sources, 1300 potential water-soluble metabolites were characterized an

SUBMITTER: Sun W 

PROVIDER: S-EPMC10608701 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature