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New Fusarin Derivatives from the Marine Algicolous Fungus Penicillium steckii SCSIO41040.

ABSTRACT: Five new fusarin derivatives, steckfusarins A-E (1-5), and two known natural products (6, 7), were isolated and identified from the marine algicolous fungus Penicillium steckii SCSIO 41040. The new compounds, including absolute configurations, were determined by spectroscopic analyses and calculated electronic circular dichroism (ECD). All new compounds were evaluated for their antioxidant, antibacterial, antifungal, antiviral, cytotoxic, anti-inflammatory, antioxidant, cholesterol-lowering, acetyl cholinesterase (AChE) enzyme and 6-phosphofructo-2-kinase (PFKFB3) and phosphatidylinositol-3-kinase (PI3K) inhibitory activities. The biological evaluation results revealed that compound 1 exhibited radical scavenging activity against 2,2-diphenyl-1-picrylhydrazylhydrate (DPPH), with an IC₅₀ value of 74.5 µg/mL. In addition, compound 1 also showed weak anti-inflammatory activity at a concentration of 20 µM.

SUBMITTER: Song Y

PROVIDER: S-EPMC10608775 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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New Fusarin Derivatives from the Marine Algicolous Fungus Penicillium steckii SCSIO41040.

Song Yingying Y She Jianglian J Chen Weihao W Wang Jiamin J Tan Yanhui Y Pang Xiaoyan X Zhou Xuefeng X Wang Junfeng J Liu Yonghong Y

Marine drugs 20231012 10

Five new fusarin derivatives, steckfusarins A-E (1-5), and two known natural products (6, 7), were isolated and identified from the marine algicolous fungus Penicillium steckii SCSIO 41040. The new compounds, including absolute configurations, were determined by spectroscopic analyses and calculated electronic circular dichroism (ECD). All new compounds were evaluated for their antioxidant, antibacterial, antifungal, antiviral, cytotoxic, anti-inflammatory, ant ...[more]

PMID: 37888468

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