Proof-of-concept optimization of a copper-mediated ¹⁸F-radiosynthesis of a novel MAGL PET tracer on a high-throughput microdroplet platform and its macroscale translation.

ABSTRACT: Copper-mediated radiofluorination has demonstrated remarkable potential in forming aromatic C-¹⁸F bonds of radioligands for positron emission tomography (PET). Achieving optimal results often requires optimization efforts, requiring a substantial amount of radiolabeling precursor and time, severely limiting the experimental throughput. Recently, we successfully showcased the feasibility of performing and optimizing Cu-mediated radiosynthesis on a high-throughput microdroplet platform using the well-known and clinically used radioligand [¹⁸F]FDOPA as an illustrative example. In our current work, we optimized the Cu-mediated synthesis of a novel monoacylglycerol lipase (MAGL) PET tracer ([¹⁸F]YH149), showing the versatility of droplet-based techniques for ear

SUBMITTER: Lu Y 

PROVIDER: S-EPMC10608794 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature