Identification of Clinically Relevant Brain Endothelial Cell Biomarkers in Plasma.

ABSTRACT:

Background

Proteins expressed by brain endothelial cells (BECs), the primary cell type of the blood-brain barrier, may serve as sensitive plasma biomarkers for neurological and neurovascular conditions, including cerebral small vessel disease.

Methods

Using data from the BLSA (Baltimore Longitudinal Study of Aging; n=886; 2009-2020), BEC-enriched proteins were identified among 7268 plasma proteins (measured with SomaScanv4.1) using an automated annotation algorithm that filtered endothelial cell transcripts followed by cross-referencing with BEC-specific transcripts reported in single-cell RNA-sequencing studies. To identify BEC-enriched proteins in plasma most relevant to the maintenance of neurological and neurovascular health, we selected proteins significantly associated

SUBMITTER: Cordon J 

PROVIDER: S-EPMC10608795 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature