Monophasic Variant of Salmonella Typhimurium Infection Affects the Serum Metabolome in Swine.

ABSTRACT: Salmonella is the most relevant foodborne zoonotic agent found in swine, and its presence in French herds is significant. Its carriage is asymptomatic, which makes it difficult to detect during rearing, thus increasing the risk of its presence on pork meat. Studies have shown that enteric infection in animals could be associated with changes in the serum metabolome composition, through the immune response or changes in the digestive microbiota composition. We hypothesized that these changes in the serum metabolome composition could be used as markers for the detection of asymptomatic animals infected by Salmonella. Using untargeted analysis by liquid chromatography coupled with mass spectrometry, we showed that significant differences in the composition of the serum metabolom

SUBMITTER: Lariviere-Gauthier G 

PROVIDER: S-EPMC10608901 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature