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Deep Eutectic Solvent Coated Cerium Oxide Nanoparticles Based Polysulfone Membrane to Mitigate Environmental Toxicology.

ABSTRACT: In this study, ceria nanoparticles (NPs) and deep eutectic solvent (DES) were synthesized, and the ceria-NP's surfaces were modified by DES to form DES-ceria NP filler to develop mixed matrix membranes (MMMs). For the sake of interface engineering, MMMs of 2%, 4%, 6% and 8% filler loadings were fabricated using solution casting technique. The characterizations of SEM, FTIR and TGA of synthesized membranes were performed. SEM represented the surface and cross-sectional morphology of membranes, which indicated that the filler is uniformly dispersed in the polysulfone. FTIR was used to analyze the interaction between the filler and support, which showed there was no reaction between the polymer and DES-ceria NPs as all the peaks were consistent, and TGA provided the variation in the membrane materials with respect to temperature, which categorized all of the membranes as very stable and showed that the trend of stability increases with respect to DES-ceria NPs filler loading. For the evaluation of efficiency of the MMMs, the gas permeation was tested. The permeability of CO₂ was improved in comparison with the pristine Polysulfone (PSF) membrane and enhanced selectivities of 35.43 (α_CO2/CH4) and 39.3 (α_CO2/N2) were found. Hence, the DES-ceria NP-based MMMs proved useful in mitigating CO₂ from a gaseous mixture.

SUBMITTER: Saif-Ur-Rehman

PROVIDER: S-EPMC10609010 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature

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Deep Eutectic Solvent Coated Cerium Oxide Nanoparticles Based Polysulfone Membrane to Mitigate Environmental Toxicology.

Saif-Ur-Rehman Shozab Mehdi Muhammad M Fakhar-E-Alam Muhammad M Asif Muhammad M Rehman Javed J A Alshgari Razan R Jamal Muddasar M Uz Zaman Shafiq S Umar Muhammad M Rafiq Sikander S Muhammad Nawshad N Bin Fawad Junaid J Shafiee Saiful Arifin SA

Molecules (Basel, Switzerland) 20231019 20

In this study, ceria nanoparticles (NPs) and deep eutectic solvent (DES) were synthesized, and the ceria-NP's surfaces were modified by DES to form DES-ceria NP filler to develop mixed matrix membranes (MMMs). For the sake of interface engineering, MMMs of 2%, 4%, 6% and 8% filler loadings were fabricated using solution casting technique. The characterizations of SEM, FTIR and TGA of synthesized membranes were performed. SEM represented the surface and cross-sectional morphology of membranes, wh ...[more]

PMID: 37894641

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Project description:Background and aimsThe occurrence of endothelial alterations in the liver and in the splanchnic vasculature of cirrhotic patients and experimental models of liver diseases has been demonstrated. However, the pathological role of the portal vein endothelium in this clinical context is scarcely studied and, therefore, deserves attention. In this context, we aimed to investigate whether pathological endothelial activation occurs in the portal vein of cirrhotic rats.MethodsCirrhosis was induced in wistar rats by CCl4 inhalation. We generated immortalized endothelial cells from the portal vein of control (CT-iPVEC) and cirrhotic rats (CH-iPVEC) by retroviral transduction of the SV40 T antigen. We assessed differential gene expression and intracellular reactive oxygen species (ROS) levels in iPVECs and in portal veins of control and cirrhotic rats. Finally, we assessed the therapeutic effectiveness of cerium oxide nanoparticles (CeO2NP) on reversing PVEC activation and macrophage polarization.ResultsCH-iPVECs overexpressed collagen-I, endothelin-1, TIMP-1, TIMP-2, IL-6 and PlGF genes. These results were consistent with the differential expression showed by whole portal veins from cirrhotic rats. In addition, CH-iPVECs showed a significant increase in intracellular ROS and the capacity of potentiating M1 polarization in macrophages. The treatment of CH-iPVECs with CeO2NPs blocked intracellular ROS formation and IL-6 and TIMP-2 gene overexpression. In agreement with the in vitro results, the chronic treatment of cirrhotic rats with CeO2NPs also resulted in the blockade of both ROS formation and IL-6 gene overexpression in whole portal veins.ConclusionsEndothelial cells from portal vein of cirrhotic rats depicted an abnormal phenotype characterized by a differential gene expression and the induction of M1 polarization in macrophages. We identified the excess of intracellular reactive oxygen species (ROS) as a major contributor to this altered phenotype. In addition, we demonstrated the utility of the nanomaterial cerium oxide as an effective antioxidant capable of reverse some of these pathological features associated with the portal vein in the cirrhosis condition.

Dataset Information

Deep Eutectic Solvent Coated Cerium Oxide Nanoparticles Based Polysulfone Membrane to Mitigate Environmental Toxicology.

Publications

Deep Eutectic Solvent Coated Cerium Oxide Nanoparticles Based Polysulfone Membrane to Mitigate Environmental Toxicology.

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