In Vivo Trafficking of the Anticancer Drug Tris(8-Quinolinolato) Gallium (III) (KP46) by Gallium-68/67 PET/SPECT Imaging.

ABSTRACT: KP46 (tris(hydroxyquinolinato)gallium(III)) is an experimental, orally administered anticancer drug. Its absorption, delivery to tumours, and mode of action are poorly understood. We aimed to gain insight into these issues using gallium-67 and gallium-68 as radiotracers with SPECT and PET imaging in mice. [⁶⁷Ga]KP46 and [⁶⁸Ga]KP46, compared with [⁶⁸Ga]gallium acetate, were used for logP measurements, in vitro cell uptake studies in A375 melanoma cells, and in vivo imaging in mice bearing A375 tumour xenografts up to 48 h after intravenous (tracer level) and oral (tracer and bulk) administration. ⁶⁸Ga was more efficiently accumulated in A375 cells in vitro when presented as [⁶⁸Ga]KP46 than as [⁶⁸Ga]gallium acetate, but

SUBMITTER: Darwesh AMF 

PROVIDER: S-EPMC10609081 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature