Maternal Diet Determines Milk Microbiome Composition and Offspring Gut Colonization in Wistar Rats.

ABSTRACT: Mother's milk contains a unique microbiome that plays a relevant role in offspring health. We hypothesize that maternal malnutrition during lactation might impact the microbial composition of milk and affect adequate offspring gut colonization, increasing the risk for later onset diseases. Then, Wistar rats were fed ad libitum (Control, C) food restriction (Undernourished, U) during gestation and lactation. After birth, offspring feces and milk stomach content were collected at lactating day (L)4, L14 and L18. The V3-V4 region of the bacterial 16S rRNA gene was sequenced to characterize bacterial communities. An analysis of beta diversity revealed significant disparities in microbial composition between groups of diet at L4 and L18 in both milk, and fecal samples. In total, 24 phyla were i

SUBMITTER: Martinez-Oca P 

PROVIDER: S-EPMC10609248 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature