Chemical Profiling and Biological Activity of Psydrax dicoccos Gaertn.

ABSTRACT: Breast cancer is one of the deadliest diseases in women with a mortality rate of 6.6%. Adverse effects of synthetic drugs have directed research toward safer alternatives such as natural compounds. This study focused on Psydrax dicoccos Gaertn, an evergreen tree abundantly distributed in Tamil Nadu (India) for its possible application against breast cancer cells. P. dicoccos leaf methanol extract, found within a wide range of phytochemicals, demonstrated cytotoxic effects against MCF7 breast cancer cells at IC₅₀ of 34 μg/mL. The extract exhibited good antioxidant activities against DPPH^• (62%) and ABTS^•+ (80%), as well as concentration-dependent (100-800 μg/mL) anti-inflammatory potential of 18-60% compared to standards, ascorbic acid or aspir

SUBMITTER: Veeramuthu K 

PROVIDER: S-EPMC10609380 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature