Multi-Omics Analysis Reveals Age-Related Microbial and Metabolite Alterations in Non-Human Primates.

ABSTRACT: Aging is a systemic physiological degenerative process, with alterations in gut microbiota and host metabolism. However, due to the interference of multiple confounding factors, aging-associated molecular characteristics have not been elucidated completely. Therefore, based on 16S ribosomal RNA (rRNA) gene sequencing and non-targeted metabolomic detection, our study systematically analyzed the composition and function of the gut microbiome, serum, and fecal metabolome of 36 male rhesus monkeys spanning from 3 to 26 years old, which completely covers juvenile, adult, and old stages. We observed significant correlations between 41 gut genera and age. Moreover, 86 fecal and 49 serum metabolites exhibited significant age-related correlations, primarily categorized into lipids and lipid-like mo

SUBMITTER: Chen X 

PROVIDER: S-EPMC10609416 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature