Numerical Mechanistic Modelling of Drug Release from Solvent-Removal Zein-Based In Situ Gel.

ABSTRACT: The development of effective drug delivery systems remains a focus of extensive research to enhance therapeutic outcomes. Among these, in situ forming gels (ISG) have emerged as a promising avenue for controlled drug release. This research focuses on the mathematical modeling of levofloxacin HCl (Lv) release from zein-based ISG using the cup method, aiming to mimic the environment of a periodontal pocket. The drug release behavior of the ISGs was investigated through experimental observations and numerical simulations employing forward and central difference formula. Notably, the experimental data for drug release from the 20% w/w zein-based ISG formulations closely aligned with the simulations obtained from numerical mechanistic modeling. In summary, 20% w/w ze

SUBMITTER: Senarat S 

PROVIDER: S-EPMC10609933 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature