^99mTc-Labeled FAPI SPECT Imaging in Idiopathic Pulmonary Fibrosis: Preliminary Results.

ABSTRACT:

Aim

Idiopathic pulmonary fibrosis (IPF) is associated with a poor prognosis, presenting the most aggressive form of interstitial lung diseases (ILDs). Activated fibroblasts are crucial for pathological processes. Fibroblast activation protein (FAP) inhibitor (FAPI) tracers would be promising imaging agents for these diseases. The purpose of this study was to evaluate a ^99mTc-labeled FAPI tracer, ^99mTc-HFAPI imaging in IPF patients.

Methods

Eleven IPF patients (nine males and two females; age range 55-75 year) were included in this pilot study. ^99mTc-HFAPI serial whole-body scintigraphy at 5 min, 20 min, 40 min, 1 h, 2 h, 3 h, 4 h, and 6 h was acquired for dynamic biodistribution and dosimetry estimation in seven representative patients. SPECT

SUBMITTER: Liu Y 

PROVIDER: S-EPMC10610005 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature