The Preparation and Evaluation of Cyanocobalamin Mucoadhesive Sublingual Tablets.

ABSTRACT: Cobalamin (vitamin B₁₂), an essential vitamin with low oral bioavailability, plays a vital role in cellular functions. This research aimed to enhance the absorption of vitamin B₁₂ using sublingual mucoadhesive tablets by increasing the residence time of the drug at the administration site. This research involved the preparation of different 50 mg placebo formulas using different methods. Formulas with disintegration times less than one minute and appropriate physical characteristics were incorporated into 1 mg of cyanocobalamin (S1-S20) using the direct compression method. The tablets obtained were evaluated ex vivo for residence time, and only those remaining for >15 min were included. The final formulas (S5, S8, S11, and S20) were evaluated in several ways, includin

SUBMITTER: Ma'ali A 

PROVIDER: S-EPMC10610133 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature