Characterization of mRNA Signature in Milk Small Extracellular Vesicles from Cattle Infected with Bovine Leukemia Virus.

ABSTRACT: This study aimed to characterize the mRNA signature of milk small extracellular vesicles (sEVs) from BLV-infected cattle. A total of 23 mRNAs, which showed greater abundance in milk sEVs from BLV-infected cattle compared to those from BLV-uninfected (control) cattle, were identified through microarray analyses conducted in our previous study. To assess the significance of these differences in mRNA abundance, milk was collected from six control cattle and twenty-six cattle infected with BLV. The infected cattle were categorized into two distinct groups based on their proviral loads: a group of eight cattle with low proviral loads (LPVL), characterized by <10,000 copies per 10⁵ white blood cells (WBC), and a group of eighteen cattle with high proviral loads (HPVL), marked by ≥10,0

SUBMITTER: Rahman MM 

PROVIDER: S-EPMC10610248 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature