Design, Synthesis, and Biological Evaluation of a Novel [¹⁸F]-Labeled Arginine Derivative for Tumor Imaging.

ABSTRACT: To better diagnose and treat tumors related to arginine metabolism, (2S,4S)-2-amino-4-(4-(2-(fluoro-¹⁸F)ethoxy)benzyl)-5-guanidinopentanoic acid ([¹⁸F]7) was designed and prepared by introducing [¹⁸F]fluoroethoxy benzyl on carbon-4 of arginine. [¹⁸F]7 and 7 were successfully prepared using synthesis methods similar to those used for (2S,4S)-4-[¹⁸F]FEBGln and (2S,4S)-4-FEBGln, respectively. In vitro experiments on cell transport mechanisms showed that [¹⁸F]7 was similar to (2S,4S)4-[¹⁸F]FPArg and was transported into tumor cells by cationic amino acid transporters. However, [¹⁸F]7 can also enter MCF-7 cells via ASC and ASC2 amino acid transporters. Further microPET-CT i

SUBMITTER: Huang Y 

PROVIDER: S-EPMC10610273 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature