Searching for Effective Treatments in HFpEF: Implications for Modeling the Disease in Rodents.

ABSTRACT:

Background

While the prevalence of heart failure with preserved ejection fraction (HFpEF) has increased over the last two decades, there still remains a lack of effective treatment. A key therapeutic challenge is posed by the absence of animal models that accurately replicate the complexities of HFpEF. The present review summarizes the effects of a wide spectrum of therapeutic agents on HF.

Methods

Two online databases were searched for studies; in total, 194 experimental protocols were analyzed following the PRISMA protocol.

Results

A diverse range of models has been proposed for studying therapeutic interventions for HFpEF, with most being based on pressure overload and systemic hypertension. They have been used to evaluate more than 150 different substances includi

SUBMITTER: Jasinska-Stroschein M 

PROVIDER: S-EPMC10610318 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature