Fc-Engineered Therapeutic Antibodies: Recent Advances and Future Directions.

ABSTRACT: Monoclonal therapeutic antibodies have revolutionized the treatment of cancer and other diseases. Fc engineering aims to enhance the effector functions or half-life of therapeutic antibodies by modifying their Fc regions. Recent advances in the Fc engineering of modern therapeutic antibodies can be considered the next generation of antibody therapy. Various strategies are employed, including altering glycosylation patterns via glycoengineering and introducing mutations to the Fc region, thereby enhancing Fc receptor or complement interactions. Further, Fc engineering strategies enable the generation of bispecific IgG-based heterodimeric antibodies. As Fc engineering techniques continue to evolve, an expanding portfolio of Fc-engineered antibodies is advancing through clinical development,

SUBMITTER: Abdeldaim DT 

PROVIDER: S-EPMC10610324 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature