Molecular Characterisation of M. kansasii Isolates by Whole-Genome Sequencing.

ABSTRACT: M. kansasii is the most common non-tuberculous mycobacteria, known to be causing pulmonary and extrapulmonary diseases in humans. Based on molecular methods, M. kansasii has been previously classified into seven different subtypes. Now, based on whole-genome sequence analysis, a new species designation was proposed, in which M. kansasii species was designated subtype 1 and is of pathogenic significance in both immunocompetent and immunocompromised patients. The aim of the study is to examine the distribution of subtypes, based on whole-genome sequence analysis, and identify the genetic determinants of drug resistance for the isolates. Whole-genome sequencing was performed using 12 isolates for which phenotypic DST results were available. A phylogenetic tree was constru

SUBMITTER: Rajendran P 

PROVIDER: S-EPMC10610326 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature