Predicting Maternal and Infant Tetrahydrocannabinol Exposure in Lactating Cannabis Users: A Physiologically Based Pharmacokinetic Modeling Approach.

ABSTRACT: A knowledge gap exists in infant tetrahydrocannabinol (THC) data to guide breastfeeding recommendations for mothers who use cannabis. In the present study, a paired lactation and infant physiologically based pharmacokinetic (PBPK) model was developed and verified. The verified model was used to simulate one hundred virtual lactating mothers (mean age: 28 years, body weight: 78 kg) who smoked 0.32 g of cannabis containing 14.14% THC, either once or multiple times. The simulated breastfeeding conditions included one-hour post smoking and subsequently every three hours. The mean peak concentration (C_max) and area under the concentration-time curve (AUC_{(0-24 h)}) for breastmilk were higher than in plasma (C_max: 155 vs. 69.9 ng/mL; AUC_{(0-24 h)}: 924.9 v

SUBMITTER: Shenkoya B 

PROVIDER: S-EPMC10610403 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature