A Roadmap for a Consensus Human Skin Cell Atlas and Single-Cell Data Standardization.

ABSTRACT: Single-cell technologies have become essential to driving discovery in both basic and translational investigative dermatology. Despite the multitude of available datasets, a central reference atlas of normal human skin, which can serve as a reference resource for skin cell types, cell states, and their molecular signatures, is still lacking. For any such atlas to receive broad acceptance, participation by many investigators during atlas construction is an essential prerequisite. As part of the Human Cell Atlas project, we have assembled a Skin Biological Network to build a consensus Human Skin Cell Atlas and outline a roadmap toward that goal. We define the drivers of skin diversity to be considered when selecting sequencing datasets for the atlas and list practical hurdles during skin sam

SUBMITTER: Almet AA 

PROVIDER: S-EPMC10610458 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature