Modulation of Gut Microbiome Community Mitigates Multiple Sclerosis in a Mouse Model: The Promising Role of Palmaria palmata Alga as a Prebiotic.

ABSTRACT:

Background

Red marine algae have shown the potential to reduce inflammation, influence microbiota, and provide neuroprotection.

Objective

To examine the prebiotic properties of Palmaria palmata aqueous extract (Palmaria p.) and its potential as a neuroprotective agent in multiple sclerosis (MS).

Methods

eighty-eight adult Swiss mice were divided into four male and four female groups, including a control group (distilled water), Palmaria p.-treated group (600 mg/kg b.w.), cuprizone (CPZ)-treated group (mixed chow 0.2%), and a group treated with both CPZ and Palmaria p. The experiment continued for seven weeks. CPZ treatment terminated at the end of the 5th week, with half of the mice sacrificed to assess the demyelination stage. To examine t

SUBMITTER: Yousof SM 

PROVIDER: S-EPMC10610500 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature