Single Nucleotide Variants in the TLR1, TLR2 and TLR6 Genes: A Case-Control Study in a Colombian Population.

ABSTRACT:

Background

Single nucleotide variants in toll-like receptor genes play a crucial role in leprosy susceptibility or resistance.

Methods

With an epidemiology case-control study, associations between SNVs rs5743618 in TLR1, rs5743708 in TLR2, and rs5743810 in TLR6 and overall susceptibility for leprosy were estimated in 114 cases and 456 controls. Following that, stratified analysis was performed. DNA was extracted from peripheral blood. Genotyping was performed using predesigned TaqMan probes.

Results

The A/G genotype of rs5743810 behaved as a protective factor for the development of leprosy in the codominant (OR= 0.37; 95% CI = 016-0.86, p = 0.049) and over-dominant (OR = 0.38; 95% CI = 0.16-0.88, p = 0.019) inheritance models. The A/G and A/A genotypes b

SUBMITTER: Gutierrez-Castaneda LD 

PROVIDER: S-EPMC10610572 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature