CXCR3 Provides a Competitive Advantage for Retention of Mycobacterium tuberculosis-Specific Tissue-Resident Memory T Cells Following a Mucosal Tuberculosis Vaccine.

ABSTRACT: Mycobacterium tuberculosis is a major human pathogen, and new vaccines are needed to prevent transmission. Mucosal vaccination may confer protection against M. tuberculosis by stimulating tissue-resident memory (T_RM) CD4⁺ T cells in the lungs. The chemokine receptor CXCR3 promotes lung recruitment of T cells, but its role in T_RM development is unknown. This study demonstrates the recombinant influenza A virus vaccine PR8.p25, expressing the immunodominant M. tuberculosis T cell epitope p25, induces CXCR3 expression on p25-specific CD4⁺ T cells in the lungs so that the majority of vaccine-induced CD4⁺ T_RM expresses CXCR3 at 6 weeks. However, CXCR3^-/- mice developed equivalent antigen-specific C

SUBMITTER: Armitage E 

PROVIDER: S-EPMC10611282 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature