Immune Profile Determines Response to Vaccination against COVID-19 in Kidney Transplant Recipients.

ABSTRACT:

Background and aim

Immune status profile can predict response to vaccination, while lymphocyte phenotypic alterations represent its effectiveness. We prospectively evaluated these parameters in kidney transplant recipients (KTRs) regarding Tozinameran (BNT162b2) vaccination.

Method

In this prospective monocenter observational study, 39 adult KTRs, on stable immunosuppression, naïve to COVID-19, with no protective humoral response after two Tozinameran doses, received the third vaccination dose, and, based on their immunity activation, they were classified as responders or non-responders. Humoral and cellular immunities were assessed at predefined time points (T₀: 48 h before the first, T₁: 48 h prior to the third and T₂: three weeks after the

SUBMITTER: Stai S 

PROVIDER: S-EPMC10611345 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature