Characterization of the Hemolytic Activity of Mastoparan Family Peptides from Wasp Venoms.

ABSTRACT: Biologically active peptides have attracted increasing attention in research on the development of new drugs. Mastoparans, a group of wasp venom linear cationic α-helical peptides, have a variety of biological effects, including mast cell degranulation, activation of protein G, and antimicrobial and anticancer activities. However, the potential hemolytic activity of cationic α-helical peptides greatly limits the clinical applications of mastoparans. Here, we systematically and comprehensively studied the hemolytic activity of mastoparans based on our wasp venom mastoparan family peptide library. The results showed that among 55 mastoparans, 18 had strong hemolytic activity (EC₅₀ ≤ 100 μM), 14 had modest hemolytic activity (100 μM < EC₅₀ ≤ 400 μM) and 23 had little hem

SUBMITTER: Ye X 

PROVIDER: S-EPMC10611374 | biostudies-literature | 2023 Sep

REPOSITORIES: biostudies-literature