Crotoxin Modulates Macrophage Phenotypic Reprogramming.

ABSTRACT: Macrophage plasticity is a fundamental feature of the immune response since it favors the rapid and adequate change of the functional phenotype in response to the pathogen or the microenvironment. Several studies have shown that Crotoxin (CTX), the major toxin of the Crotalus durissus terrificus snake venom, has a long-lasting antitumor effect both in experimental models and in clinical trials. In this study, we show the CTX effect on the phenotypic reprogramming of macrophages in the mesenchymal tumor microenvironment or those obtained from the peritoneal cavity of healthy animals. CTX (0.9 or 5 μg/animal subcutaneously) administered concomitantly with intraperitoneal inoculation of tumor cells (1 × 10⁷/0.5 mL, injected intraperitoneally) of Ehrlich Ascitic Tumor (EAT) m

SUBMITTER: Neves CL 

PROVIDER: S-EPMC10611389 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature