Reorganization of the functional connectome from rest to a visual perception task in schizophrenia and bipolar disorder.

ABSTRACT: Functional connectome organization is altered in schizophrenia (SZ) and bipolar disorder (BD). However, it remains unclear whether network reorganization during a task relative to rest is also altered in these disorders. This study examined connectome organization in patients with SZ (N = 43) and BD (N = 42) versus healthy controls (HC; N = 39) using fMRI data during a visual object-perception task and at rest. Graph analyses were conducted for the whole-brain network using indices selected a priori: three reflecting network segregation (clustering coefficient, local efficiency, modularity), two reflecting integration (characteristic path length, global efficiency). Group differences were limited to network segregation and were more evident in SZ (clustering coefficient, modularity) than i

SUBMITTER: Riedel P 

PROVIDER: S-EPMC10611423 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature