Transcriptional responses of liver and spleen in Lota lota to polyriboinosinic polyribocytidylic acid.

ABSTRACT:

Introduction

The cultured Lota lota can meet the market demand in the context of the decline of wild resources, but the disease in the high-density culture process also deserves attention. Therefore, understanding the immune regulation mechanisms of L. lota will be the basis for obtaining high benefits in artificial culture.

Methods

To explore the viral response mechanism of L. lota, RNA-seq was applied to identify the transcriptomic changes of the liver and spleen in L. lota by poly (I:C) stress.

Results

The DEGs (liver: 2186 to 3123; spleen 1542 to 2622) and up-regulated genes (liver: 1231 to 1776; spleen 769 to 1502) in the liver and spleen increased with the prolongation (12h to 48h) of poly (I:C)-stimulation time. This means L. lota

SUBMITTER: Lou F 

PROVIDER: S-EPMC10611466 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature