Dataset Information

Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients.

ABSTRACT:

Introduction

Chronic pain negatively impacts a range of sensory and affective behaviors. Previous studies have shown that the presence of chronic pain not only causes hypersensitivity at the site of injury but may also be associated with pain-aversive experiences at anatomically unrelated sites. While animal studies have indicated that the cingulate and prefrontal cortices are involved in this generalized hyperalgesia, the mechanisms distinguishing increased sensitivity at the site of injury from a generalized site-nonspecific enhancement in the aversive response to nociceptive inputs are not well known.

Methods

We compared measured pain responses to peripheral mechanical stimuli applied to a site of chronic pain and at a pain-free site in participants suffering from chronic lower back pain (n = 15) versus pain-free control participants (n = 15) by analyzing behavioral and electroencephalographic (EEG) data.

Results

As expected, participants with chronic pain endorsed enhanced pain with mechanical stimuli in both back and hand. We further analyzed electroencephalographic (EEG) recordings during these evoked pain episodes. Brain oscillations in theta and alpha bands in the medial orbitofrontal cortex (mOFC) were associated with localized hypersensitivity, while increased gamma oscillations in the anterior cingulate cortex (ACC) and increased theta oscillations in the dorsolateral prefrontal cortex (dlPFC) were associated with generalized hyperalgesia.

Discussion

These findings indicate that chronic pain may disrupt multiple cortical circuits to impact nociceptive processing.

SUBMITTER: Kenefati G

PROVIDER: S-EPMC10611481 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature

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Publications

Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients.

Kenefati George G Rockholt Mika M MM Ok Deborah D McCartin Michael M Zhang Qiaosheng Q Sun Guanghao G Maslinski Julia J Wang Aaron A Chen Baldwin B Voigt Erich P EP Chen Zhe Sage ZS Wang Jing J Doan Lisa V LV

Frontiers in neuroscience 20231013

<h4>Introduction</h4>Chronic pain negatively impacts a range of sensory and affective behaviors. Previous studies have shown that the presence of chronic pain not only causes hypersensitivity at the site of injury but may also be associated with pain-aversive experiences at anatomically unrelated sites. While animal studies have indicated that the cingulate and prefrontal cortices are involved in this generalized hyperalgesia, the mechanisms distinguishing increased sensitivity at the site of in ...[more]

PMID: 37901433

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Project description:IntroductionVisual spatial attention can be captured by a salient color singleton that is contingent on the target feature. A previous study reported that theta (4-7 Hz) and alpha (8-14 Hz) oscillations were related to contingent attentional capture, but the corresponding attentional mechanisms of these oscillations remain unclear.MethodsIn this study, we analyzed the electroencephalogram data of our previous study to investigate the roles of capture-related theta and alpha oscillation activities. Different from the previous study that used color-changed placeholders as irrelevant cues, the present study adopted abrupt onsets of color singleton cues which tend to elicit phase-locked neural activities. In Experiment 1, participants completed a peripheral visual search task in which spatially uninformative color singleton cues were inside the spatial attentional window and a central rapid serial visual presentation (RSVP) task in which the same cues were outside the spatial attentional window. In Experiment 2, participants completed a color RSVP task and a size RSVP task in which the peripheral color singleton cues were contingent and not contingent on target feature, respectively.ResultsIn Experiment 1, spatially uninformative color singleton cues elicited lateralized theta activities when they were contingent on target feature, irrespective of whether they were inside or outside the spatial attentional window. In contrast, the same color singleton cues elicited alpha lateralization only when they were inside the spatial attentional window. In Experiment 2, we further found that theta lateralization vanished if the color singleton cues were not contingent on target feature.DiscussionThese results suggest distinct roles of theta and alpha oscillations in the process of contingent attentional capture initiated by abrupt onsets of singleton cues. Theta activities may reflect global enhancement of target feature, while alpha activities may be related to attentional engagement to spatially relevant singleton cues. These lateralized neural oscillations, together with the distractor-elicited N2pc component, might consist of multiple stages of attentional processes during contingent attentional capture.

Dataset Information

Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients.

Introduction

Methods

Results

Discussion

Publications

Changes in alpha, theta, and gamma oscillations in distinct cortical areas are associated with altered acute pain responses in chronic low back pain patients.

Similar Datasets

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