Isoform switching leads to downregulation of cytokine producing genes in estrogen receptor positive breast cancer.

ABSTRACT: Objective: Estrogen receptor breast cancer (BC) is characterized by the expression of estrogen receptors. It is the most common cancer among women, with an incidence rate of 2.26 million cases worldwide. The aim of this study was to identify differentially expressed genes and isoform switching between estrogen receptor positive and triple negative BC samples. Methods: The data were collected from ArrayExpress, followed by preprocessing and subsequent mapping from HISAT2. Read quantification was performed by StringTie, and then R package ballgown was used to perform differential expression analysis. Functional enrichment analysis was conducted using Enrichr, and then immune genes were shortlisted based on the ScType marker database. Isoform switch analysis was also performed u

SUBMITTER: Khan MS 

PROVIDER: S-EPMC10611502 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature