A bibliometric analysis: Ca²⁺ fluxes and inflammatory phenotyping by flow cytometry in peripheral blood mononuclear cells.

ABSTRACT:

Background

The immune system, composed of organs, tissues, cells, and proteins, is the key to protecting the body from external biological attacks and inflammation. The latter occurs in several pathologies, such as cancers, type 1 diabetes, and human immunodeficiency virus infection. Immunophenotyping by flow cytometry is the method of choice for diagnosing these pathologies. Under inflammatory conditions, the peripheral blood mononuclear cells (PBMCs) are partially activated and generate intracellular pathways involving Ca²⁺-dependent signaling cascades leading to transcription factor expression. Ca²⁺ signaling is typically studied by microscopy in cell lines but can present some limitations to explore human PBMCs, where flow cytometry can be a good alternati

SUBMITTER: Brun C 

PROVIDER: S-EPMC10611513 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature