Temperament & Character account for brain functional connectivity at rest: A diathesis-stress model of functional dysregulation in psychosis.

ABSTRACT: The human brain's resting-state functional connectivity (rsFC) provides stable trait-like measures of differences in the perceptual, cognitive, emotional, and social functioning of individuals. The rsFC of the prefrontal cortex is hypothesized to mediate a person's rational self-government, as is also measured by personality, so we tested whether its connectivity networks account for vulnerability to psychosis and related personality configurations. Young adults were recruited as outpatients or controls from the same communities around psychiatric clinics. Healthy controls (n = 30) and clinically stable outpatients with bipolar disorder (n = 35) or schizophrenia (n = 27) were diagnosed by structured interviews, and then were assessed with standardized protocols of the Human Connectome Proj

SUBMITTER: Zwir I 

PROVIDER: S-EPMC10611583 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature