[¹⁸F] AlF‑NOTA‑FAPI‑04 PET/CT as a promising tool for imaging fibroblast activation protein in gastrointestinal system cancers: a prospective investigation of comparative analysis with ¹⁸F-FDG.

ABSTRACT:

Purpose

The radiopharmaceutical [¹⁸F]AlF-NOTA-FAPI-04 presents a promising alternative to ⁶⁸ Ga-FAPI owing to its relatively longer half-life. This study aimed to evaluate the clinical usefulness of [¹⁸F]AlF-NOTA-FAPI-04 PET/CT for the diagnosis of primary and metastatic lesions in various types of gastrointestinal system cancers, compared with ¹⁸F-FDG PET/CT.

Methods

Patients diagnosed with gastrointestinal system malignancies were prospectively enrolled. All patients underwent both ¹⁸F-FDG and ¹⁸F-FAPI-04 PET/CT scans within one week, with 44 (73.3%) for cancer staging and 16 (26.7%) for tumor restaging. Diagnostic efficacy of the primary tumor, as well as the presence and number of lymph nodes and distant m

SUBMITTER: Yang L 

PROVIDER: S-EPMC10611594 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature