Association between nutrient intake related to the one-carbon metabolism and colorectal cancer risk: a case-control study in the Basque Country.

ABSTRACT:

Purpose

Epidemiologic evidence for the association between methyl-donor nutrient intake and colorectal cancer (CRC) risk remains inconclusive. We aimed to examine the relationship between intake of vitamins of the B group, methionine, total choline and betaine and CRC risk, in a population from the CRC screening programme in the Basque Country.

Design

This observational study included 308 patients with CRC and 308 age- and sex-matched subjects as controls. During recruitment, dietary, anthropometric, lifestyle, socioeconomic, demographic, and health status information was collected. Conditional logistic regression was used to estimate the odds ratios (ORs) for CRC risk.

Results

The adjusted ORs for CRC risk decreased with higher intakes of choline and betaine (p < 0.0

SUBMITTER: Martin-Fernandez-de-Labastida S 

PROVIDER: S-EPMC10611602 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature