Design of novel anti-quorum sensing peptides targeting LuxO to combat Vibrio cholerae pathogenesis.

ABSTRACT: Vibrio cholerae, the Gram-negative bacterium abruptly colonizes the human intestine causing diarrhea, employing quorum sensing (QS) system as the major survival technique for mediating biofilm formation, virulence, competence, etc. Two distinct QS systems coordinated by the auto-inducer molecules, cholera-specific CqsA/S system and universal LuxS/PQ system, operate in parallel converging into a common phosphorelay pathway involving LuxU and LuxO. The master regulatory proteins of the QS system, AphA and HapR regulate the biofilm formation based on cell density, whose expression is controlled by the global response regulator LuxO. At low cell density, activated LuxO indirectly represses HapR, favoring the virulence cascade expression. Rather at high cell densities, LuxO represses Aph

SUBMITTER: Murugesan J 

PROVIDER: S-EPMC10611667 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature