A network pharmacology approach to explore pharmacological mechanisms of <i>Asparagus racemosus</i> for ameliorative effect in epilepsy and comorbid progressive memory dysfunction.

ABSTRACT:

Background

Network pharmacology approach has been observed a powerful tool to predict underlying complex pharmacological mechanism of herbs. Asparagus racemosus has been reported to show ameliorative effects in treating epilepsy and comorbid memory dysfunction but mechanism of this amelioration is elusive. Hence a network pharmacology approach was employed to investigate the plausible mechanism of A. recemosus.

Methodology

: Bioactive compounds of A. racemosus were extracted based on the TCMSP, PCIDB, and BATMAN-TCM database. The potential targets of bioactive compounds were collected using target fishing. Epilepsy and comorbid dementia genes were collected from DISGENET. A PPI network among these targets was constructed using the intersecting key

SUBMITTER: Kaur B 

PROVIDER: S-EPMC10611688 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature