New thresholds in semi-quantitative [¹⁸F]FDG PET/CT are needed to assess large vessel vasculitis with long-axial field-of-view scanners.

ABSTRACT:

Aim

[¹⁸F]FDG PET/CT proved accurate in the diagnostic work-up of large vessel vasculitis (LVV). While a visual interpretation is currently considered adequate, several attempts have been made to integrate it with a semiquantitative evaluation. In this regard, there is the need to validate current or new thresholds for the semiquantitative parameters on long-axial field of view (LAFOV) scanners.

Methods

We retrospectively evaluated 100 patients (50 with LVV and 50 controls) who underwent [¹⁸F]FDG LAFOV PET/CT. Semiquantitative parameters (SUVmax and SUVmean) were calculated for large vessels in 3 districts (supra-aortic [SA], thoracic aorta [TA], and infra-aortic [IA]). Values were also normalized to liver activity (SUV_max/L-SUV_max,

SUBMITTER: Knappe L 

PROVIDER: S-EPMC10611821 | biostudies-literature | 2023 Nov

REPOSITORIES: biostudies-literature