Antimicrobial Drug-Drug Interactions in the Treatment of Infectious Keratitis.

ABSTRACT:

Purpose

Infectious keratitis is a serious disease requiring immediate, intensive, and broad-spectrum empiric treatment to prevent vision loss. Given the diversity of organisms that can cause serious corneal disease, current guidelines recommend treatment with several antimicrobial agents simultaneously to provide adequate coverage while awaiting results of microbiology cultures. However, it is currently unknown how the use of multiple ophthalmic antimicrobial agents in combination may affect the efficacy of individual drugs.

Methods

Using a panel of 9 ophthalmic antibiotics, 3 antifungal agents, and 2 antiacanthamoeba therapeutics, fractional inhibitory concentration testing in the standard checkerboard format was used to study 36 antibiotic-antibiotic combinations, 27 antib

SUBMITTER: Dunster E 

PROVIDER: S-EPMC10611897 | biostudies-literature | 2023 Dec

REPOSITORIES: biostudies-literature