Repeated Human Exposure to Semivolatile Organic Compounds by Inhalation: Novel Protocol for a Nonrandomized Study.

ABSTRACT:

Background

Semivolatile organic compounds (SVOCs) comprise several different chemical families used mainly as additives in many everyday products. SVOCs can be released into the air as aerosols and deposit on particulate matter during use by dispersion, evaporation, or abrasion. Phthalates are SVOCs of growing concern due to their endocrine-disrupting effects. Human data on the absorption, distribution, metabolism, and excretion (ADME) of these compounds upon inhalation are almost nonexistent.

Objective

The goal of this study is to develop a method for repeated inhalation exposures to SVOCs to characterize their ADME in humans.

Methods

We will use diethylhexyl phthalate (DEHP), a major indoor air pollutant, as a model SVOC in this novel protocol. The Swiss official Co

SUBMITTER: Reale E 

PROVIDER: S-EPMC10612011 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature