Structural Investigations of Interactions between the Influenza a Virus NS1 and Host Cellular Proteins.

ABSTRACT: The Influenza A virus is a continuous threat to public health that causes yearly epidemics with the ever-present threat of the virus becoming the next pandemic. Due to increasing levels of resistance, several of our previously used antivirals have been rendered useless. There is a strong need for new antivirals that are less likely to be susceptible to mutations. One strategy to achieve this goal is structure-based drug development. By understanding the minute details of protein structure, we can develop antivirals that target the most conserved, crucial regions to yield the highest chances of long-lasting success. One promising IAV target is the virulence protein non-structural protein 1 (NS1). NS1 contributes to pathogenicity through interactions with numerous host proteins, and many of

SUBMITTER: Blake ME 

PROVIDER: S-EPMC10612106 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature