Durable effects of deep brain ultrasonic neuromodulation on major depression: a case report.

ABSTRACT:

Background

Severe forms of depression have been linked to hyperactivity of the subcallosal cingulate cortex. The ability to stimulate the subcallosal cingulate cortex or associated circuits noninvasively and directly would maximize the number of patients who could receive treatment. To this end, we have developed an ultrasound-based device for effective noninvasive modulation of deep brain circuits. Here we describe an application of this tool to an individual with treatment-resistant depression.

Case presentation

A 30-year-old Caucasian woman with severe treatment-resistant non-psychotic depression was recruited into a clinical study approved by the Institutional Review Board of the University of Utah. The patient had a history of electroconvulsive therapy with full remissi

SUBMITTER: Riis TS 

PROVIDER: S-EPMC10612153 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature